Lost in Translation: Nerve Growth Factor in Diabetic Retinopathy

Dr. Azza B. El-Remessy
Augusta Biomedical Research Corporation, Charlie Norwood VA Medical Center, Downtown 6B-153, Augusta, GA 30912, USA.

SKU: LTNGFDR Category: Tag:

Book Details

Author(s)

Dr. Azza B. El-Remessy

Pages

215

Publisher

Book Publisher International

Language

English

ISBN-13 (15)

978-93-5547-253-3 (Print)
978-93-5547-258-8 (eBook)

Published

November 03, 2021

About The Author / Editor

Dr. Azza B. El-Remessy

Augusta Biomedical Research Corporation, Charlie Norwood VA Medical Center, Downtown 6B-153, Augusta, GA 30912, USA.

Diabetic retinopathy, the blinding disease for working-age Americans, has limited therapeutic options. Thus, there is a great need to identify published evidence that shows that diabetes triggers expression of nerve growth factor (NGF), yet retinal neurodegeneration continues to happen, leading to vision loss. As detailed in this book, Dr. El-Remessy’s work unraveled the paradox of increased NGF and progression of diabetic retinopathy. Her group made the discovery that diabetes-associated nitrative stress inhibits the survival signal of the TrkA receptor and hampers the proteolytic cleavage and maturation of the NGF precursor (proNGF) to its mature form. The next chapter details the contribution of proNGF and its receptor p75NTR to mediate various aspects of diabetic retinopathy. Unique animal models that were developed to study cleavage-resistant proNGF are compiled in a separate chapter. The next chapter contains therapeutic modalities to harness endogenous trophic support and prevent the progression of diabetic retinopathy. Finally, review articles of relevance to the NGF and molecular targets of diabetic retinopathy are included in the last chapter.

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